hematology - lymfoid gene panels

Lab Test name Contact Comments
CHU Liège - Hemato hematology - lymfoid gene panels Dr Frédéric LAMBERT
NGS targeted sequencing after hybridization capture, Home brew assay; ISO15189 accreditation from BELAC.
Targets: TP53; BIRC3; NOTCH1; ATM; IKAROS, PAX5, JAK1/2/3; TYK2; PTEN; RAS; TP53; FBXW7; CRLF2; MYD88; CXCR4; BRAF; STAT3; STA5B; TP53; TCF3; ID3; NOTCH1&2; RhoA
Full genes list available upon request.

Could be done for:

- CLL pronostic (TP53; BIRC3; NOTCH1; ATM...)
- B & T-ALL diagnosis & prognostication (IKAROS, PAX5, JAK1/2/3; TYK2; PTEN; RAS; TP53; FBXW7,...)
- Lymphoïd disorders differential including CLL; Hairy cell leukemia, lymphoplasmocytic lymphoma, burkitt; AITL; LGL.
CHU Liège - Hemato hematology - lymfoid gene panels Dr Frédéric LAMBERT & Benjamin KOOPMANSCH
Inherited Syndromes Predisposing to Adult-Onset Hematologic Malignancy:
Familial B-cell ALL with PAX5; Germline SH2B3; Li-Fraumeni syndrome with ALL or therapy-related AML (TP53)

NGS targeted sequencing after hybridization capture, Home brew assay; ISO15189 accreditation from BELAC.

Skin biopsy requested or fibroblasts'DNA.

INFORMED CONSENT REQUESTED BEFORE TESTING:
http://www.chu.ulg.ac.be/jcms/c_10919499/formulaire-de-consentement-ngs
UZ Leuven MolPLUZ hematology - lymfoid gene panels Lucienne Michaux / Els Lierman
Sample type: blood / bone marrow (EDTA, 2-5 ml)
Frequency: 1x/week
Test type: TruSight Myeloid (Illumina), NGS
Genes: BRAF, FBXW7, IKZF1, MYD88, NOTCH1, PTEN, SF3B1, TP53, ...
Accredited:
UZ Leuven MolPLUZ hematology - lymfoid gene panels Lucienne Michaux / Els Lierman
Sample type: blood / bone marrow (EDTA, 2-5 ml)
Frequency: 1x/week
Test type: MLPA for detection of micro-deletions and -duplications in B-ALL (SALSA MLPA probemix P335-B1 ALL-IKZF1)
Genes: EBF1, IKZF1, CDKN2A, CDKN2B, PAX5, ETV6, BTG1, RB1, SHOX, CRLF2, CSF2RA, IL3RA, P2RY8
Accredited:
Jessa Hospital hematology - lymfoid gene panels Guy Froyen
2x/week
on MiSeq
Version date: 13/11/2017
Accredited:
AZ Delta hematology - lymfoid gene panels Geert Martens, Elke Boone
Sample type: blood / bone marrow (300µl - 1 ml)
Frequency: 1x/month
Test type: TruSight Myeloid (Illumina), NGS
Genes: BRAF, FBXW7, IKZF1, MYD88, NOTCH1, PTEN, SF3B1, TP53, ...
Version date: 05/12/2017
Accredited: