Abelson (ABL1) mutation analysis

Detection of mutations in the ABL kinase (ATP binding domain and P-loop). Resistance mechanism to Gleevec, Dasatinib, etc.
Lab Test name Contact Comments
IPG Gosselies Abelson (ABL1) mutation analysis P. Vannuffel
C. De Rop
Mutation analysis of ABL1 tyrosine kinase domain
NGS AmpliSeq - IonTorrent
Sample type: Blood and bone marrow
BELAC accreditation number: 381-MED
Version date: 02/09/2022
LHUB-ULB Abelson (ABL1) mutation analysis Pierre Heimann/Barbara Dessars/Hakim El Housni
based on Branford S et al. protocol
PCR on cDNA followed by sequence analysis

UZ Leuven MolPLUZ Abelson (ABL1) mutation analysis Jolien De Bie
Sample type: blood / bone marrow (EDTA, 2-5 ml)
Frequency: 1x/week
Test type: digital droplet PCR (ddPCR) on DNA with PrimePCR ddPCR Mutation Assay (Bio-Rad) for BCR-ABL1 p.Q252H, p.Y253H, p.E255K, p.T315I, p.F317L, p.F359V
BELAC accreditation number 215-MED