Abelson (ABL1) mutation analysis

Detection of mutations in the ABL kinase (ATP binding domain and P-loop). Resistance mechanism to Gleevec, Dasatinib, etc.

Lab	Test name	Contact	Comments
IPG Gosselies	Abelson (ABL1) mutation analysis	P. Vannuffel C. De Rop	Mutation analysis of ABL1 tyrosine kinase domain NGS AmpliSeq - IonTorrent Sample type: Blood and bone marrow BELAC accreditation number: 381-MED Version date: 02/09/2022 Accredited:
LHUB-ULB	Abelson (ABL1) mutation analysis	Pierre Heimann/Barbara Dessars/Hakim El Housni	based on Branford S et al. protocol PCR on cDNA followed by sequence analysis
UZ Leuven MolPLUZ	Abelson (ABL1) mutation analysis	Jolien De Bie	Sample type: blood / bone marrow (EDTA, 2-5 ml) Frequency: 1x/week Test type: digital droplet PCR (ddPCR) on DNA with PrimePCR ddPCR Mutation Assay (Bio-Rad) for BCR-ABL1 p.Q252H, p.Y253H, p.E255K, p.T315I, p.F317L, p.F359V BELAC accreditation number 215-MED Accredited: