MPL mutation analysis

Lab Test name Contact Comments
AZ St-Jan Brugge - Laboratoriumgeneeskunde MPL mutation analysis dr. Helena Devos/Friedel Nollet, Ph.D.
PCR amplification (on DNA) + DNA sequencing for detection of S505 and W515 mutations in the MPL gene.
Version date: 04/11/2017
Accredited:
CHU Liège - Hemato MPL mutation analysis Dr Frédéric LAMBERT
3 ml EDTA anticoagulated bone marrow.
Inherited/familial thrombocytosis.
UZ Leuven MolPLUZ MPL mutation analysis Lucienne Michaux / Els Lierman
Sample type: blood / bone marrow (EDTA, 2-5 ml)
Frequency: 1x/week
Test type: PCR on DNA (exon 10) + Sanger sequencing (in house method)
Accredited:
UZ Gent MPL mutation analysis Karl Vandepoele,
Joni Van Der Meulen,
Barbara Denys
In-house developed NGS panel to screen clinically relevant genes in MPN and MDS/MPN overlap:
CALR, CSF3R, JAK2, MPL, SETBP1 and SRSF2

Also available in a cost-effective mini-panel: JAK2, CALR and MPL
Version date: 18/08/2017
Accredited: