MPL mutation analysis

Lab Test name Contact Comments
AZ St-Jan Brugge - Laboratoriumgeneeskunde MPL mutation analysis dr. Helena Devos/Friedel Nollet, Ph.D.
PCR amplification (on DNA) + DNA sequencing for detection of S505 and W515 mutations in the MPL gene.
Version date: 04/11/2017
CHU Liège - Hemato MPL mutation analysis Dr Frédéric LAMBERT
3 ml EDTA anticoagulated bone marrow.
Inherited/familial thrombocytosis.

BELAC accreditation number: 128-MED

33 Nomenclature
UZ Leuven MolPLUZ MPL mutation analysis Jolien De Bie
Sample type: blood / bone marrow (EDTA, 2-5 ml)
Frequency: 1x/week
Test type: PCR on DNA (exon 10)
BELAC accreditation number 215-MED
UZ Gent MPL mutation analysis Karl Vandepoele,
Joni Van Der Meulen,
Barbara Denys
In-house developed NGS panel to screen clinically relevant genes in MPN and MDS/MPN overlap:
BELAC accreditation number 087-MED

These genes are also present in the larger 68 gene panel.

Also available in a cost-effective mini-panel: JAK2, CALR and MPL
Version date: 16/03/2021
LHUB-ULB MPL mutation analysis Pierre Heimann/Laurent Dewispelaere/Pascale Cochaux/Hakim El Housni
SAMPLE TYPE: Peripheral Blood (5mL) or bone marrow (EDTA, 1-2 mL)
TRANSPORT: room temperature, within 24h after sampling
FREQUENCY: variable: max TAT: 4 weeks
TEST TYPE: MPL is analyzed in several in-house developed NGS panels designed to refine diagnosis and prognosis of MPN and MDS/MPN overlap syndrome.
BELAC accreditation number 650-MED
Version date: 04/10/2021