Calreticulin (CALR) mutation analysis

Lab Test name Contact Comments
UZ Brussel - Molecular Hematology Calreticulin (CALR) mutation analysis Marleen Bakkus/Barbara Depreter
PCR on genomic DNA from blood or bone marrow followed by capillary electrophoresis. Ref: Klampfl et al. NEJM 2013; 369: 2379-90.
BELAC accrediation number: 141-MED
Version date: 12/04/2023
UZ Leuven MolPLUZ Calreticulin (CALR) mutation analysis Jolien De Bie
Sample type: blood / bone marrow (EDTA, 2-5 ml)
Frequency: 1x/week
Test type: PCR on DNA (ref: Klampf et al, NEJM 2013; exon 9)
BELAC accreditation number 215-MED
AZ St-Jan Brugge - Laboratoriumgeneeskunde Calreticulin (CALR) mutation analysis dr. Helena Devos/Friedel Nollet, Ph.D.
method : PCR and capillary electropheresis. Sensitivity 5%
Version date: 04/11/2017
LHUB-ULB Calreticulin (CALR) mutation analysis Pierre Heimann/Laurent Dewispelaere/Pascale Cochaux/Hakim El Housni
SAMPLE TYPE: Peripheral blood (5mL) or bone marrow (EDTA, 1-2 mL)
TRANSPORT: room temperature, within 24h after sampling
FREQUENCY: variable: max TAT: 4 weeks
TEST TYPE: CALR is analyzed in several in-house developed NGS panels designed to refine diagnosis and prognosis of MPN and MDS/MPN overlap syndrome.
BELAC accreditation number 650-MED
Version date: 04/10/2021
UZ Gent Calreticulin (CALR) mutation analysis Karl Vandepoele,
Annelynn Wallaert
Joni Van Der Meulen,
Barbara Denys
In-house developed NGS panel to screen clinically relevant genes in MPN and MDS/MPN overlap:
BELAC accreditation number 087-MED

These genes are also present in the larger 116 genes NGS panel.
Version date: 31/05/2023
AZ Delta Calreticulin (CALR) mutation analysis Geert Martens, Elke Boone
SAMPLE TYPE: Blood or bone marrow (1ml, EDTA)
FREQUENCY: upon request
TEST TYPE: PCR & Fragment analysis (exon 9 indel),
Version date: 05/12/2017
IPG Gosselies Calreticulin (CALR) mutation analysis P. Vannuffel
C. De Rop
In-house method based on Klampfl et al, N Engl J Med, 2013.
Capillary electrophoresis.
Sample type: Blood and bone marrow.
BELAC accreditation number: 381-MED.
Version date: 07/09/2022