MYD88 L265P mutation analysis

Detection of MYD88 c.794T>C (p.Leu265Pro)
Lab Test name Contact Comments
CUB Erasme - Medical Genetics Dpt MYD88 L265P mutation analysis Pierre Heimann/Barbara Dessars/Hakim El Housni
Real-Time fluorescent LNA-blocking PCR

Analytical sensitivity : 5%
CHU Li├Ęge - Hemato MYD88 L265P mutation analysis Dr. Sc. Sabine FRANKE
3ml EDTA bone marrow or fresh lymph node biopsy.

Diagnosis of Waldenstrom macroglobulinemia (WM) or lymphoplasmacytic leukemia (LPL);

Work-up of DLBCL NHL ABC versus GC-like.
AZ St-Jan Brugge - Laboratoriumgeneeskunde MYD88 L265P mutation analysis dr. Helena Devos/Friedel Nollet, Ph.D.
real time PCR with blocking LNA primer (sensitivity 1% mutant DNA); DNA test
Version date: 04/11/2017
Accredited:
UZ Gent MYD88 L265P mutation analysis Barbara Denys,
Karl Vandepoele
Detection of the MYD88 c.794C>T mutation (L265P)
qPCR with LNA blocker which allows selective amplification of the mutated allele

FREQUENCY: 1x/week
Version date: 21/08/2018
Accredited:
UZ Leuven MolPLUZ MYD88 L265P mutation analysis Lucienne Michaux / Els Lierman
Sample type: blood / bone marrow (EDTA, 2-5 ml)
Frequency: 1x/week
Test type: PCR on DNA, adapted from Treon et al., 2012. N Engl J Med
Accredited:
UZ Brussel - Molecular Hematology MYD88 L265P mutation analysis Marleen Bakkus/Christian Demanet
Detection of the MYD88 c.794C>T mutation (L265P).
QPCR with LNA blocker, sensitivity 1% mutated allele.
Version date: 26/09/2017